Updated 01/31/2022
When Did Michael Jackson Die?
25th June 2009 was a regular day like any other until the world received shocking news on the untimely death of ‘The King of Pop’ Michael Jackson as many would refer to him. His death was declared a homicide. His physician, Dr. Conrad Murray, was later charged and convicted in a court of law for administering the drugs that killed the pop star. An autopsy revealed that acute propofol intoxication was the primary cause of his death. So, what drug killed Michael Jackson? Let’s find out!
On the previous day, the pop star was rehearsing for his comeback tour, and with the piled-up pressure, he complained about his inability to sleep. Dr. Conrad Murray gave him a series of drugs that would help him relax, and later on, the pop star would be found unconscious. Michael Jackson was then rushed to the hospital, and he was found in cardiac arrest, and he was not breathing.https://www.youtube.com/embed/FcJwzPz_6no?feature=oembed
Efforts to resuscitate him for more than an hour were futile. Dr. Murray was found guilty of involuntary manslaughter in 2011 and thereby sentenced to a jail term of four years but only served two years as he was released on parole. Other drugs were also detected upon the completion of Michael’s autopsy, such as diazepam, lidocaine, and ephedrine.
Prosecutors accused Murray of giving the pop star Propofol in large dosage to aid in sleeping and left him unattended. The physician’s defense team said that he gave himself a powerful anesthetic overdose. The Los Angeles County coroner concluded that the pop star died from acute propofol intoxication.
What Drug Killed Michael Jackson? Propofol!
On June 25, 2009, American singer Michael Jackson died of acute propofol and benzodiazepine intoxication at his home on North Carolwood Drive in the Holmby Hills neighborhood of Los Angeles. Propofol is a short-acting drug that puts an individual asleep during general anesthesia for surgery and other medical purposes by slowing down one’s nervous system and activeness. Sometimes referred to as ‘milk of anesthesia,’ propofol is insoluble in water, and it consists of an oily, white solution that must be refrigerated before it is used.
Soybean oil, glycerol, and fats purified from egg yolks are constituents of the solution. Propofol is often regarded as safe for Individuals who are allergic to eggs since they are allergic to the proteins in eggs rather than the fat. Regardless, some people may have allergic reactions.
Most people were not familiar with propofol until the popstar’s case since anesthesiologists mainly used it. Propofol results in loss of consciousness and, therefore, is often used as an induction agent. It is also administered in lower doses for conscious sedation of Individuals getting surgical outpatient procedures.
Propofol Use as a Sodium Thiopental replacement
Propofol was introduced as a replacement induction agent for sodium thiopental, a traditional barbiturate that is no longer in the market. Sodium thiopental is often used to execute individuals with fatal injections. Therefore, some countries and groups that resist the death sentence have piled up pressure on suppliers using legal means, among other methods.
Anesthesiologists use large proportions of propofol ranging between 100-200 ml of propofol for general anesthesia, followed by smaller amounts continuously depending on an Individual’s body weight in micrograms every minute. While the drug is infused into an Individual’s vein, pain is incurred, and a local anesthetic is injected first before propofol, such as lidocaine, to ease the pain.
Since propofol reduces an Individual’s blood pressure and also restrains breathing, patients need to be continually monitored thus should not be left unattended.
Propofol for Mild Sedation
Propofol is used at times for outpatient surgical procedures as it puts Individuals in a tired, subconscious state. It neither causes nausea nor vomiting, and its duration of action lasts between five to ten minutes and typically wears off fast. Slight loss of memory may also be incurred by a patient afterward.
Propofol Abuse
Like any other drug, propofol can be prone to abuse by Individuals, causing lethal overdoses in some instances. Research studies conducted on volunteers by the University of Utah, Division of Emergency Medicine doctors, Courtney Wilson, Peter Canning, and E. Martin Cavarati showed that propofol gave anesthetic patients pleasant dreams.
It also gives pleasurable effects, and the sensational feeling is explained as a ‘high’ or ‘drunk’ state. In addition to that, they also noted that Individuals could develop propofol tolerance hence may require more of the drug to attain a high feeling. Its illegal use is more natural to conceal because of the short-acting factor that makes it wear off fast.
There were 45 recorded cases of propofol abuse, in which 40 of them involved medical practitioners, and 18 of them led to death between 1992-2009 from a medical literature search. A survey from Academic Anesthesiology Training Programs indicated that 18% of the samples of propofol abuse had happened in 10 years that is 1995-2005.
Propofol use should be regulated since it’s a controlled substance like any other potent anesthetic drug.
Is Michael Jackson dead or alive?
Michael Jackson was also known as “The King of Pop.” He is regarded to be one of the 20th century’s most influential cultural icons. Jackson was a best-selling American singer, songwriter, and dancer. He was born on Aug. 29, 1958, in Gary, Indiana. Jackson was famous as a child when he belonged to his family’s own Motown group, The Jackson 5. He became their lead singer and moved on to his own solo career.
On June 25, 2009, Michael Jackson was pronounced dead. The singer died of acute propofol and benzodiazepine intoxication in his home. He lived on North Carolwood Dr. in Holmby Hills, Los Angeles. It’s over 10 years since the King of Pop died but some fans can’t move on – the shocking, heartwarming, and downright bizarre stories that have been doing the rounds recently.
We all miss the King of Pop, but some people genuinely believe he is still alive. Yes, really. A strange conspiracy theory that Michael Jackson is still alive has been revived thanks to a lookalike baffling fans with his moonwalk.
Yet, many people have provided evidence that produces much suspicion that the singer is still alive.
Jackson’s body went into cardiac arrest, the initial cause of his death. Yet, the singer happened to have a closed casket funeral where no one could see his body. The cardiac arrest would not have done much to his physical appearance to make a closed casket a necessity. However, more controversy about his casket arose as images of an open casket holding “the body of Michael Jackson” soared across the web. Within this image of the casket, you can see an African-American man in similar attire to Jackson’s laying there. However, it has been proven that this image is false information. As one can see, the body in the image does not match the singer’s complexion due to his plastic surgery and enhancements in his later years. However, this truly raises suspicion of how information conveying his body is so mysterious.
Many people have taken up the time to dress up and role-play as the singer. They learn to sing and dance just like him which can be hard to match without such talent. However, many have come to believe that one of these role-players must be the real Jackson. These singers have gone to the point of getting the same procedures done to replicate the exact image of Jackson’s facial structure. Creepy, right?
However, this last piece of evidence is the most deceiving of them all. After Jackson’s death, he was taken away in a coroner’s van from his home in LA. Just as anyone does after death, a coroner will come and take care of the deceased body and proceed to have it prepared for the funeral. However, a video had been released of what looks to be the exact van that took his body away. Within the video, the van pulls into some sort of parking garage or unknown public area and the gates suddenly close behind it. The back doors of the van open and a man, who resembles Michael Jackson, walks out the back and into the building never to be seen again. This piece of evidence really sparks the idea that the singer is still alive and escaping away from society.
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Our brains work in truly magnificent ways. The brain literally controls every aspect of our lives. Without proper brain function, we would not be able to perform even the most basic task. Due to the fact that the brain is so complex, even the slightest of changes can completely alter the chemical makeup. Everything we do can affect how our brains react and perform. This is especially true when it comes to the consumption of drugs and alcohol. Drugs and alcohol can change the way that neurotransmitters work in the brain, which changes the user’s emotions and, ultimately, the way they think and behave.
In this blog, we will take a look at what exactly neurotransmitters are as well as answer the question of “how do drugs affect neurotransmitters?”
How Does the Brain Work?
Before we can get into how drugs work on the brain, it’s important to have an understanding of how the brain works as a whole.
The brain is like a very complex and powerful computer, controlling every aspect of the body. Instead of electrical circuits on the silicon chips that control our electronic devices though, the brain consists of billions of cells, called neurons, which are organized into circuits and networks.
Each of these neurons acts as a type of switch, controlling how information is processed and sent out. If a certain neuron receives a strong enough signal from other neurons it’s connected to, it will fire off and send its own signal to those other neurons.
Different brain circuits are responsible for coordinating and performing specific functions. Networks of neurons send signals back and forth to each other and among different parts of the brain, the spinal cord, and nerves in the rest of the body.
What Is A Neurotransmitter?
When a neuron wants to send a message, it releases something called a neurotransmitter into the gap between it and the next cell. The neurotransmitter crosses the synapse and attaches to receptors on the receiving neuron, like a key into a lock. This causes changes in the receiving cell. Neurotransmitters are what signals the brain to do certain things such as producing feelings like anger, joy, anxiety, and cravings.
How Do Drugs and Alcohol Affect the Brain and the Neurotransmitters?
As we mentioned earlier, due to the overall complexity of the brain, even the slightest change can greatly alter the way it functions. When a person takes drugs or drinks a lot of alcohol, it can interfere with the way that neurons send, receive, and process signals that are sent by the neurotransmitters.
Some drugs can actually activate neurons because of the chemical structure and makeup of the drug. They will attach to the neurons and actually help activate them. While those types of drugs might mimic the natural chemicals of the brain, they don’t activate neurons in the same way as the brain would do so naturally, which can lead to abnormal brain activity.
Other types of drugs can cause neurons to release large amounts of natural neurotransmitters. They can even prevent the normal recycling of brain chemicals by interfering with the transporters. This can cause a disruption when it comes to the communication between neurons.
Are There Specific Parts of the Brain That Are Affected By Substance Abuse?
While the entire chemical makeup of the brain can change as a result of prolonged substance abuse, there are three main areas of the brain that can be particularly affected by substance abuse more than others.
Prefrontal Cortex
The prefrontal cortex is the part of your brain that controls the ability to think, problem-solve, make decisions, plan, and have self-control. When someone has a substance abuse disorder, it can reduce their ability to control their impulses, making it “easier” to continue abusing substances. The prefrontal cortex is also the last part of the brain to mature, making teens and young adults more susceptible than others.
Basal Ganglia
The basal ganglia is the part of the brain that produces pleasure and creates motivation. It also is involved in the formation of habits and routines. These areas form a key node of what is sometimes called the brain’s “reward circuit.” When drugs are put into the body, it can cause this circuit to over-activate. This is what produces the euphoria that comes with being high. Over time though, the circuit adapts to the substances that are constantly being put into it, thus developing a higher tolerance which causes dependence and addiction.
Extended Amygdala
This part of the brain plays an active role in producing feelings of anxiety, irritability, unease, and other types of stress. This is the part of the brain that is affected once the drugs start to wear off and withdrawal symptoms begin to set in. Over time, this part of the brain will become more and more sensitive, resulting in the person needing to take more and more of the substances of abuse in order to get temporary relief from the discomfort.
In addition to these parts of the brain, some drugs can also disrupt other parts of the brain, such as the brain stem. This disruption is what can lead to serious medical complications and even overdoses.
What Types of Drugs Affect Neurotransmitters More Than Others?
Certain substances affect certain parts of the brain, and their neurotransmitters are different from others. This is based largely on the effects that the drug produces and what part of the brain it pertains to. Here are some of the more common substances of abuse and the neurotransmitter they largely affect:
Serotonin Inhibitory Neurotransmitter
This neurotransmitter works as a mood stabilizer and impacts mood, sexual desire, sleep, and appetite. The drugs that affect this neurotransmitter are:
- Cocaine
- PCP
- Ecstasy
Glutamate Excitatory Transmitter
Glutamate, also known as the major excitatory neurotransmitter, increases neuron activity and is involved in learning, memory, and cognitive functions. The drugs that most commonly affect this neurotransmitter are:
- PCP
- Alcohol
- Ketamine
Gamma-aminobutyric Acid Inhibitory Neurotransmitter
Also known as GABA, this neurotransmitter lowers stress levels and decreases feelings of anxiety by slowing down the blood pressure, heart rate, and body temperature. The substances that affect this neurotransmitter are:
- Sedatives
- Tranquilizers
- Benzos
- Alcohol
Norepinephrinean Excitatory Neurotransmitter
This neurotransmitter acts in a similar manner to adrenaline. It activates the sensations and feelings in the body most associated with adrenaline such as raised blood pressure, accelerated heart rate, and an increase in body temperature. It can also affect anxiety levels, sleep, appetite, and sensory processing abilities. This neurotransmitter is most commonly affected by:
- ADHD medications such as Adderall and Ritalin
- Cocaine
- Amphetamines
- Meth
Endogenous Cannabinoids Non-standard Neurotransmitter
This neurotransmitter interacts with the CB1 cannabinoid receptors in the brain, which impact memory, movement, and cognitive functions. Marijuana and synthetic cannabis such as spice are the two things that affect this neurotransmitter the most.
Are Neurotransmitter Problems Related to Addiction Treatable?
The good news is that while lengthy and hard, most ailments associated with substance abuse can be treated over time with the proper treatment methods.
The first step in the treatment process is to detox off of any and all harmful substances. Detoxing should be done under constant medical care and supervision at either a hospital or medical facility, a dedicated detox center, or a treatment center that also offers detox services such as CNV Detox. Attempting to detox on your own can be incredibly dangerous and even potentially life-threatening.
Once detox has been completed then treatment can begin. Your treatment professional will recommend you enter into either an inpatient or outpatient rehab program based on which option is best for you and your condition.
Behavioral therapies such as cognitive behavioral therapy (CBT) have been proven to be the most effective when it comes to restoring brain function and connectivity. CBT improves self-reliance and enhances self-esteem while teaching effective coping mechanisms and measures for preventing relapse when confronted with potential triggers. It can also help teach you healthy ways to enhance pleasure and occupy the mind without the need for illicit substances such as drugs or alcohol.
How Do Drugs Affect Neurotransmitters?
Neurotransmitters are a very sensitive part of the brain. Even the slightest change in the chemical makeup of the brain can play a significant role in how the brain operates. Prolonged use of drugs and alcohol can change the entire chemical makeup of the brain, including how the neurotransmitters function.
Contact CNV Detox for Help Today
If you or someone you know is suffering from a substance abuse disorder, it’s important to get the help you need before it’s too late. At CNV Detox, we know how important it is to live a healthy and sober life. That’s why in addition to offering detox programs, we also offer treatment programs for a variety of addictions and disorders. Contact us today to learn more about the services we provide and how we can get you on the road to recovery.